Prurigo nodularis
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Prurigo nodularis je dlhotrvajúci stav kože charakterizovaný viacerými pevnými hrbolčekmi a uzlinami, ktoré sa zvyčajne nachádzajú na vonkajších častiach rúk a nôh. Tieto hrbole môžu mať rôznu farbu od telovej až po ružovú a intenzívne svrbia. Môžu postihnúť ľudí v akomkoľvek veku a často sú spojené s inými kožnými ochoreniami, ktoré spôsobujú chronické svrbenie, ako je atopická dermatitída. Možnosti liečby zahŕňajú silné lieky proti svrbeniu, lieky ovplyvňujúce imunitný systém a lieky zamerané na nervový systém. Zvládnutie prurigo nodularis zvyčajne zahŕňa dlhodobú liečbu.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Liečba zvyčajne zahŕňa použitie krémov alebo injekcií steroidov na postihnutú oblasť. V závažnejších alebo tvrdohlavých prípadoch môžu byť potrebné liečby ako svetelná terapia alebo lieky, ktoré potláčajú imunitný systém. Thalidomid a lenalidomid sú možnosti pre ťažké prípady, ale môžu mať vážne vedľajšie účinky. Novšie liečby (opioid receptor antagonists, neurokinin-1 receptor antagonists) sú sľubné pri liečbe prurigo nodularis s menším počtom vedľajších účinkov v porovnaní s talidomidom alebo lenalidomidom.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo je kožné ochorenie charakterizované dlhotrvajúcim svrbením (trvá viac ako 6 týždňov) , kožnými léziami súvisiacimi so škrabancami a častými škrabancami v anamnéze. Zahŕňa neurozápal a fibrózu v koži.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis je dlhotrvajúci kožný problém poznačený svrbivými uzlinami. Nevieme presne, čo to spôsobuje, ale zdá sa, že v cykle svrbenia a škrabania zohrávajú úlohu imunitné a nervové problémy. V súčasnosti neexistuje žiadna liečba schválená americkým FDA špeciálne pre prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Liečba - Voľne predajné lieky
Umývanie oblasti lézie mydlom vôbec nepomáha a môže to zhoršiť. Voľne predajné steroidné masti môžu pomôcť zmierniť príznaky, ale zvyčajne je potrebné ich aplikovať niekoľko týždňov, aby sa zlepšili. Pokračovanie v užívaní antihistaminík tiež pomáha zmierniť svrbenie.
#OTC steroid ointment
#OTC antihistamine
○ Liečba
#Intralesional triamcinolone injection